| German Bundesliga |
| No. | Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 1 | 21-Aug-10 | H | Nuremberg | D | 1-1 | (1-1) | Idrissou 31 | 42,202 |
| 2 | 29-Aug-10 | A | Bayer Leverkusen | W | 6-3 | (3-1) | Herrmann 20, 44; Brouwers 40; Arango 56; Idrissou 60; Reus 69 | 30,210 |
| 3 | 11-Sep-10 | H | Eintracht Frankfurt | L | 0-4 | (0-2) | | 45,315 |
| 4 | 18-Sep-10 | A | Stuttgart | L | 0-7 | (0-2) | | 39,500 |
| 5 | 22-Sep-10 | H | St Pauli | L | 1-2 | (1-0) | Arango 25 | 41,000 |
| 6 | 25-Sep-10 | A | Schalke 04 | D | 2-2 | (2-0) | Daems 15p; Bradley 43 | 61,673 |
| 7 | 02-Oct-10 | H | Wolfsburg | D | 1-1 | (0-1) | Marx 65 | 40,423 |
| 8 | 17-Oct-10 | A | 1899 Hoffenheim | L | 2-3 | (1-0) | Bobadilla 13; Idrissou 90 | 30,150 |
| 9 | 23-Oct-10 | H | Werder Bremen | L | 1-4 | (0-2) | Mertesacker(og) 67 | 53,511 |
| 10 | 30-Oct-10 | A | Keiserlautern | L | 0-3 | (0-0) | | 49,167 |
| 11 | 06-Nov-10 | H | Bayern Munich | D | 3-3 | (1-2) | Herrmann 4; Reus 56; De Camargo 60 | 54,057 |
| 12 | 13-Nov-10 | A | FC Koln | W | 4-0 | (0-0) | Bobadilla 51, 90; Bradley 69; De Camargo 82 | 50,000 |
| 13 | 20-Nov-10 | H | FSV Mainz 05 | L | 2-3 | (0-0) | Reus 53, 69 | 45,472 |
| 14 | 27-Nov-10 | A | Borussia Dortmund | L | 1-4 | (1-1) | Reus 33 | 79,200 |
| 15 | 04-Dec-10 | H | Hannover 96 | L | 1-2 | (1-0) | Bradley 18 | 37,195 |
| 16 | 12-Dec-10 | A | Freiburg | L | 0-3 | (0-2) | | 22,700 |
| 17 | 17-Dec-10 | H | Hamburg | L | 1-2 | (0-0) | De Camargo 48 | 42,253 |
| 18 | 15-Jan-11 | A | Nuremberg | W | 1-0 | (1-0) | Neustadter 8 | 37,464 |
| 19 | 23-Jan-11 | H | Bayer Leverkusen | L | 1-3 | (0-2) | Stranzl 65 | 36,696 |
| 20 | 30-Jan-11 | A | Eintracht Frankfurt | W | 1-0 | (0-0) | De Camargo 84 | 43,700 |
| 21 | 05-Feb-11 | H | Stuttgart | L | 2-3 | (2-0) | Dante 29; De Camargo 31 | 39,132 |
| 22 | 12-Feb-11 | A | St Pauli | L | 1-3 | (1-1) | De Camargo 9 | 24,487 |
| 23 | 20-Feb-11 | H | Schalke 04 | W | 2-1 | (2-1) | Reus 12; Idrissou 23 | 51,592 |
| 24 | 25-Feb-11 | A | Wolfsburg | L | 1-2 | (0-2) | Daems 74p | 28,763 |
| 25 | 05-Mar-11 | H | 1899 Hoffenheim | W | 2-0 | (0-0) | Daems 65p; De Camargo 70 | 35,350 |
| 26 | 12-Mar-11 | A | Werder Bremen | D | 1-1 | (0-1) | Stranzl 90 | 40,500 |
| 27 | 18-Mar-11 | H | Keiserlautern | L | 0-1 | (0-0) | | 47,696 |
| 28 | 02-Apr-11 | A | Bayern Munich | L | 0-1 | (0-0) | | 69,000 |
| 29 | 10-Apr-11 | H | FC Koln | W | 5-1 | (3-0) | Arango 29; Reus 34, 39; Daems 65p; Nordtveit 67 | 53,104 |
| 30 | 15-Apr-11 | A | FSV Mainz 05 | L | 0-1 | (0-0) | | 20,300 |
| 31 | 23-Apr-11 | H | Borussia Dortmund | W | 1-0 | (1-0) | Idrissou 36 | 54,057 |
| 32 | 30-Apr-11 | A | Hannover 96 | W | 1-0 | (0-0) | Reus 75 | 48,800 |
| 33 | 07-May-11 | H | Freiburg | W | 2-0 | (0-0) | Hanke 80; Reus 82 | 49,057 |
| 34 | 14-May-11 | A | Hamburg | D | 1-1 | (1-0) | Arango 41 | 57,000 |
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| German Cup |
| Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 1 | 14-Aug-10 | A | FC Erzgebirge Aue | W | 3-1 | (1-0) | Bradley 39; Idrissou 64; Reus 87 | --,--- |
| 2 | 27-Oct-10 | H | Bayer Leverkusen | D | 1-1 | (0-0) | Idrissou 109 [aet, pen 5-4] | --,--- |
| 3 | 23-Dec-10 | A | 1899 Hoffenheim | L | 0-2 | (0-1) | | --,--- |
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Score distributions by match - goals scored by row, and goals conceded by column. Each box shows the number of this season's matches with the resulting scoreline.