| Spanish Primera Liga |
| No. | Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 1 | 28-Aug-11 | A | Sevilla FC | L | 1-2 | (0-2) | Santi Cazorla 81 | 34,000 |
| 2 | 12-Sep-11 | H | Granada Atletico | W | 4-0 | (2-0) | Santi Cazorla 5, 48; Joaquin 25, 73 | 20,000 |
| 3 | 17-Sep-11 | A | Real Mallorca | W | 1-0 | (1-0) | Demichelis 39 | 12,000 |
| 4 | 21-Sep-11 | H | Athletic Bilbao | W | 1-0 | (0-0) | Santi Cazorla 62 | 21,000 |
| 5 | 25-Sep-11 | A | Real Zaragoza | D | 0-0 | (0-0) | | 18,000 |
| 6 | 01-Oct-11 | H | Getafe | W | 3-2 | (0-0) | Van Nistelrooy 64; Maresca 88; Julio Baptista 90 | 25,000 |
| 7 | 16-Oct-11 | A | Levante | L | 0-3 | (0-3) | | 18,000 |
| 8 | 22-Oct-11 | H | Real Madrid | L | 0-4 | (0-4) | | 28,500 |
| 9 | 26-Oct-11 | A | Rayo Vallecano | L | 0-2 | (0-1) | | 10,000 |
| 10 | 30-Oct-11 | H | Espanyol | W | 2-1 | (1-1) | Rondon 5; Apono 73p | 18,000 |
| 11 | 05-Nov-11 | A | Real Betis | D | 0-0 | (0-0) | | 41,000 |
| 12 | 21-Nov-11 | A | Racing Santander | W | 3-1 | (0-0) | Isco 48; Gonzalez(og) 65; Fernandez 89 | 14,000 |
| 13 | 28-Nov-11 | H | Villarreal | W | 2-1 | (2-1) | Toulalan 4; Isco 40 | 27,500 |
| 14 | 04-Dec-11 | A | Real Sociedad | L | 2-3 | (1-1) | Rondon 21; Fernandez 59 | 25,000 |
| 15 | 11-Dec-11 | H | Osasuna | D | 1-1 | (0-1) | Juanmi 70 | 25,000 |
| 16 | 18-Dec-11 | A | Valencia | L | 0-2 | (0-1) | | 40,000 |
| 17 | 07-Jan-12 | H | Atletico Madrid | D | 0-0 | (0-0) | | 26,000 |
| 18 | 15-Jan-12 | A | Sporting Gijon | L | 1-2 | (0-1) | Van Nistelrooy 87 | 19,000 |
| 19 | 22-Jan-12 | H | Barcelona | L | 1-4 | (0-1) | Rondon 86 | 27,000 |
| 20 | 29-Jan-12 | H | Sevilla FC | W | 2-1 | (2-1) | Weligton 7; Fernandez 19 | 28,000 |
| 21 | 06-Feb-12 | A | Granada Atletico | L | 1-2 | (0-0) | Rondon 68 | 15,000 |
| 22 | 12-Feb-12 | H | Real Mallorca | W | 3-1 | (1-1) | Fernandez 11; Toulalan 55; Rondon 69 | 25,000 |
| 23 | 19-Feb-12 | A | Athletic Bilbao | L | 0-3 | (0-0) | | 38,000 |
| 24 | 25-Feb-12 | H | Real Zaragoza | W | 5-1 | (1-1) | Fernandez 45; Da Silva(og) 67; Demichelis 77; Isco 79; Rondon 88 | 25,000 |
| 25 | 03-Mar-12 | A | Getafe | W | 3-1 | (0-1) | Eliseu 57; Toulalan 82; Santi Cazorla 90 | 11,000 |
| 26 | 10-Mar-12 | H | Levante | W | 1-0 | (0-0) | Rondon 51 | 28,000 |
| 27 | 18-Mar-12 | A | Real Madrid | D | 1-1 | (0-1) | Santi Cazorla 90 | 78,000 |
| 28 | 22-Mar-12 | H | Rayo Vallecano | W | 4-2 | (1-1) | Rondon 35, 58; Maresca 70; Duda 86 | 26,000 |
| 29 | 25-Mar-12 | A | Espanyol | W | 2-1 | (0-1) | Van Nistelrooy 76; Demichelis 78 | 24,000 |
| 30 | 31-Mar-12 | H | Real Betis | L | 0-2 | (0-2) | | 28,000 |
| 31 | 09-Apr-12 | H | Racing Santander | W | 3-0 | (1-0) | Isco 22; Santi Cazorla 64; Van Nistelrooy 84 | 28,000 |
| 32 | 12-Apr-12 | A | Villarreal | L | 1-2 | (0-0) | Santi Cazorla 65 | 17,000 |
| 33 | 15-Apr-12 | H | Real Sociedad | D | 1-1 | (1-0) | Isco 19 | 27,500 |
| 34 | 23-Apr-12 | A | Osasuna | D | 1-1 | (0-0) | Santi Cazorla 67 | 20,000 |
| 35 | 29-Apr-12 | H | Valencia | W | 1-0 | (1-0) | Camacho 27 | 28,000 |
| 36 | 02-May-12 | A | Barcelona | L | 1-4 | (1-2) | Rondon 26 | 88,000 |
| 37 | 05-May-12 | A | Atletico Madrid | L | 1-2 | (1-0) | Eliseu 38 | 25,000 |
| 38 | 13-May-12 | H | Sporting Gijon | W | 1-0 | (0-0) | Rondon 49 | 27,000 |
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| Spanish Cup |
| Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 4 L1 | 13-Dec-11 | A | Getafe | W | 1-0 | (0-0) | Lopez 84 | --,--- |
| 4 L2 | 21-Dec-11 | H | Getafe | D | 2-2 | (1-0) | Van Nistelrooy 45; Rende 86 | --,--- |
| 5 L1 | 03-Jan-12 | A | Real Madrid | L | 2-3 | (2-0) | Sanchez 10; Demichelis 29 | --,--- |
| 5 L2 | 10-Jan-12 | H | Real Madrid | L | 0-1 | (0-0) | | --,--- |
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Score distributions by match - goals scored by row, and goals conceded by column. Each box shows the number of this season's matches with the resulting scoreline.