| English Premier League |
| No. | Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 1 | 13-Aug-11 | H | Aston Villa | D | 0-0 | (0-0) | | 25,700 |
| 2 | 21-Aug-11 | A | Wolverhampton Wndrs | L | 0-2 | (0-2) | | 22,657 |
| 3 | 28-Aug-11 | A | Newcastle United | L | 1-2 | (0-0) | Dempsey 88 | 42,684 |
| 4 | 11-Sep-11 | H | Blackburn Rovers | D | 1-1 | (1-1) | Zamora 38 | 24,856 |
| 5 | 18-Sep-11 | H | Manchester City | D | 2-2 | (0-1) | Zamora 55; Murphy 75 | 24,750 |
| 6 | 24-Sep-11 | A | West Bromwich Albion | D | 0-0 | (0-0) | | 23,835 |
| 7 | 02-Oct-11 | H | Queens Park Rangers | W | 6-0 | (3-0) | Johnson 2, 38, 59; Murphy 20p; Dempsey 65; Zamora 74 | 23,766 |
| 8 | 15-Oct-11 | A | Stoke City | L | 0-2 | (0-0) | | 26,890 |
| 9 | 23-Oct-11 | H | Everton | L | 1-3 | (0-1) | Ruiz 67 | 25,646 |
| 10 | 29-Oct-11 | A | Wigan Athletic | W | 2-0 | (1-0) | Dempsey 41; Dembele 86 | 15,796 |
| 11 | 06-Nov-11 | H | Tottenham Hotspur | L | 1-3 | (0-2) | Kaboul(og) 57 | 25,698 |
| 12 | 19-Nov-11 | A | Sunderland | D | 0-0 | (0-0) | | 37,688 |
| 13 | 26-Nov-11 | A | Arsenal | D | 1-1 | (0-0) | Vermaelen(og) 65 | 60,043 |
| 14 | 05-Dec-11 | H | Liverpool | W | 1-0 | (0-0) | Dempsey 85 | 25,688 |
| 15 | 10-Dec-11 | A | Swansea City | L | 0-2 | (0-0) | | 19,296 |
| 16 | 17-Dec-11 | H | Bolton Wanderers | W | 2-0 | (2-0) | Dempsey 32; Ruiz 34 | 25,643 |
| 17 | 21-Dec-11 | H | Manchester United | L | 0-5 | (0-3) | | 25,700 |
| 18 | 26-Dec-11 | A | Chelsea | D | 1-1 | (0-0) | Dempsey 56 | 41,548 |
| 19 | 31-Dec-11 | A | Norwich City | D | 1-1 | (1-0) | Orlando Sa 7 | 26,406 |
| 20 | 02-Jan-12 | H | Arsenal | W | 2-1 | (0-1) | Sidwell 85; Zamora 90 | 25,700 |
| 21 | 14-Jan-12 | A | Blackburn Rovers | L | 1-3 | (0-1) | Duff 56 | 18,003 |
| 22 | 21-Jan-12 | H | Newcastle United | W | 5-2 | (0-1) | Murphy 52p; Dempsey 59, 65, 89; Zamora 68p | 25,692 |
| 23 | 01-Feb-12 | H | West Bromwich Albion | D | 1-1 | (0-0) | Dempsey 69 | 25,689 |
| 24 | 04-Feb-12 | A | Manchester City | L | 0-3 | (0-2) | | 46,963 |
| 25 | 11-Feb-12 | H | Stoke City | W | 2-1 | (2-0) | Pogrebnyak 16; Sorensen(og) 28 | 23,555 |
| 26 | 25-Feb-12 | A | Queens Park Rangers | W | 1-0 | (1-0) | Pogrebnyak 7 | 18,015 |
| 27 | 04-Mar-12 | H | Wolverhampton Wndrs | W | 5-0 | (2-0) | Pogrebnyak 36, 44, 61; Dempsey 56, 83 | 24,034 |
| 28 | 10-Mar-12 | A | Aston Villa | L | 0-1 | (0-0) | | 32,372 |
| 29 | 17-Mar-12 | H | Swansea City | L | 0-3 | (0-1) | | 25,690 |
| 30 | 26-Mar-12 | A | Manchester United | L | 0-1 | (0-1) | | 75,570 |
| 31 | 31-Mar-12 | H | Norwich City | W | 2-1 | (2-0) | Dempsey 2; Duff 13 | 25,700 |
| 32 | 07-Apr-12 | A | Bolton Wanderers | W | 3-0 | (2-0) | Dempsey 30, 45; Diarra 80 | 21,939 |
| 33 | 09-Apr-12 | H | Chelsea | D | 1-1 | (0-1) | Dempsey 82 | 25,697 |
| 34 | 21-Apr-12 | H | Wigan Athletic | W | 2-1 | (0-0) | Pogrebnyak 58; Senderos 89 | 25,689 |
| 35 | 28-Apr-12 | A | Everton | L | 0-4 | (0-3) | | 31,885 |
| 36 | 01-May-12 | A | Liverpool | W | 1-0 | (1-0) | Skrtel(og) 5 | 40,106 |
| 37 | 06-May-12 | H | Sunderland | W | 2-1 | (2-1) | Dempsey 12; Dembele 35 | 25,683 |
| 38 | 13-May-12 | A | Tottenham Hotspur | L | 0-2 | (0-1) | | 36,256 |
|
|
| FA Cup |
| Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 3 | 07-Jan-12 | H | Charlton Athletic | W | 4-0 | (1-0) | Dempsey 8, 61, 81p; Duff 87 | 20,317 |
| 4 | 27-Jan-12 | A | Everton | L | 1-2 | (1-1) | Murphy 14p | 25,300 |
|
|
| League Cup |
| Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 3 | 21-Sep-11 | A | Chelsea | D | 0-0 | (0-0) | [aet, pen 4-3] | 37,632 |
|
|
| Europa League Finals |
| Date | Ven | Opponent | Result | HT | Scorers | Attend |
| Gp k | 15-Sep-11 | H | FC Twente | D | 1-1 | (1-1) | Johnson 19 | 14,110 |
| Gp k | 29-Sep-11 | A | Odense BK | W | 2-0 | (1-0) | Johnson 36, 88 | 6,500 |
| Gp k | 20-Oct-11 | A | Wisla Kraków | L | 0-1 | (0-0) | | 28,000 |
| Gp k | 03-Nov-11 | H | Wisla Kraków | W | 4-1 | (2-1) | Duff 5; Johnson 30, 57; Sidwell 79 | 20,319 |
| Gp k | 01-Dec-11 | A | FC Twente | L | 0-1 | (0-0) | | 21,000 |
| Gp k | 14-Dec-11 | H | Odense BK | D | 2-2 | (2-0) | Dempsey 27; Frei 31 | 15,757 |
|
|
| Europa League Qual |
| Date | Ven | Opponent | Result | HT | Scorers | Attend |
| Q1 L1 | 30-Jun-11 | H | Runavik | W | 3-0 | (1-0) | Duff 32; Murphy 61p; Johnson 71 | 14,910 |
| Q1 L2 | 07-Jul-11 | A | Runavik | D | 0-0 | (0-0) | | 1,245 |
| Q2 L1 | 14-Jul-11 | A | Crusaders | W | 3-1 | (1-0) | Briggs 40; Zamora 75; Murphy 77p | 3,011 |
| Q2 L2 | 21-Jul-11 | H | Crusaders | W | 4-0 | (1-0) | Johnson 19; Duff 56; Zamora 67; Sidwell 70 | 15,676 |
| Q3 L1 | 28-Jul-11 | A | RNK Split | D | 0-0 | (0-0) | | --,--- |
| Q3 L2 | 04-Aug-11 | H | RNK Split | W | 2-0 | (1-0) | Johnson 18; Murphy 57p | --,--- |
| PO L1 | 18-Aug-11 | H | Dnipro Dnipropetrovsk | W | 3-0 | (2-0) | Hughes 38; Dempsey 43, 49 | --,--- |
| PO L2 | 25-Aug-11 | A | Dnipro Dnipropetrovsk | L | 0-1 | (0-1) | | 12,100 |
|
|
Score distributions by match - goals scored by row, and goals conceded by column. Each box shows the number of this season's matches with the resulting scoreline.