| English Premier League |
| No. | Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 1 | 20-Aug-11 | H | Queens Park Rangers | L | 0-1 | (0-1) | | 35,008 |
| 2 | 27-Aug-11 | A | Blackburn Rovers | W | 1-0 | (0-0) | Arteta 90p | 22,826 |
| 3 | 10-Sep-11 | H | Aston Villa | D | 2-2 | (1-0) | Osman 19; Baines 69p | 32,736 |
| 4 | 17-Sep-11 | H | Wigan Athletic | W | 3-1 | (1-1) | Jagielka 33; Vellios 84; Drenthe 90 | 31,576 |
| 5 | 24-Sep-11 | A | Manchester City | L | 0-2 | (0-0) | | 47,293 |
| 6 | 01-Oct-11 | H | Liverpool | L | 0-2 | (0-0) | | 39,510 |
| 7 | 15-Oct-11 | A | Chelsea | L | 1-3 | (0-2) | Vellios 81 | 41,789 |
| 8 | 23-Oct-11 | A | Fulham | W | 3-1 | (1-0) | Drenthe 3; Rodwell 90; Saha 90 | 25,646 |
| 9 | 29-Oct-11 | H | Manchester United | L | 0-1 | (0-1) | | 35,494 |
| 10 | 05-Nov-11 | A | Newcastle United | L | 1-2 | (1-2) | Rodwell 45 | 50,671 |
| 11 | 19-Nov-11 | H | Wolverhampton Wndrs | W | 2-1 | (1-1) | Jagielka 44; Baines 83p | 33,953 |
| 12 | 26-Nov-11 | A | Bolton Wanderers | W | 2-0 | (0-0) | Fellaini 49; Vellios 78 | 24,058 |
| 13 | 04-Dec-11 | H | Stoke City | L | 0-1 | (0-1) | | 33,219 |
| 14 | 10-Dec-11 | A | Arsenal | L | 0-1 | (0-0) | | 60,062 |
| 15 | 17-Dec-11 | H | Norwich City | D | 1-1 | (0-1) | Osman 81 | 31,004 |
| 16 | 21-Dec-11 | H | Swansea City | W | 1-0 | (0-0) | Osman 60 | 32,004 |
| 17 | 26-Dec-11 | A | Sunderland | D | 1-1 | (0-1) | Baines 51p | 43,619 |
| 18 | 01-Jan-12 | A | West Bromwich Albion | W | 1-0 | (0-0) | Anichebe 87 | 23,038 |
| 19 | 04-Jan-12 | H | Bolton Wanderers | L | 1-2 | (0-0) | Howard 63 | 29,561 |
| 20 | 11-Jan-12 | A | Tottenham Hotspur | L | 0-2 | (0-1) | | 36,132 |
| 21 | 14-Jan-12 | A | Aston Villa | D | 1-1 | (0-0) | Anichebe 69 | 31,853 |
| 22 | 21-Jan-12 | H | Blackburn Rovers | D | 1-1 | (1-0) | Cahill 24 | 32,464 |
| 23 | 31-Jan-12 | H | Manchester City | W | 1-0 | (0-0) | Gibson 60 | 29,856 |
| 24 | 04-Feb-12 | A | Wigan Athletic | D | 1-1 | (0-0) | Anichebe 83 | 18,340 |
| 25 | 11-Feb-12 | H | Chelsea | W | 2-0 | (1-0) | Pienaar 5; Stracqualursi 71 | 33,924 |
| 26 | 03-Mar-12 | A | Queens Park Rangers | D | 1-1 | (1-1) | Drenthe 31 | 18,033 |
| 27 | 10-Mar-12 | H | Tottenham Hotspur | W | 1-0 | (1-0) | Jelavic 22 | 34,992 |
| 28 | 13-Mar-12 | A | Liverpool | L | 0-3 | (0-1) | | 44,921 |
| 29 | 21-Mar-12 | H | Arsenal | L | 0-1 | (0-1) | | 30,330 |
| 30 | 24-Mar-12 | A | Swansea City | W | 2-0 | (0-0) | Baines 59; Jelavic 76 | 20,509 |
| 31 | 31-Mar-12 | H | West Bromwich Albion | W | 2-0 | (1-0) | McAuley(og) 18; Anichebe 68 | 32,051 |
| 32 | 07-Apr-12 | A | Norwich City | D | 2-2 | (1-1) | Jelavic 22, 61 | 26,554 |
| 33 | 09-Apr-12 | H | Sunderland | W | 4-0 | (0-0) | Gueye 52; Pienaar 75; Osman 76; Anichebe 81 | 32,249 |
| 34 | 22-Apr-12 | A | Manchester United | D | 4-4 | (1-1) | Jelavic 33, 83; Fellaini 67; Pienaar 85 | 75,522 |
| 35 | 28-Apr-12 | H | Fulham | W | 4-0 | (3-0) | Jelavic 7p, 40; Fellaini 16; Cahill 60 | 31,885 |
| 36 | 01-May-12 | A | Stoke City | D | 1-1 | (1-0) | Crouch(og) 44 | 26,500 |
| 37 | 06-May-12 | A | Wolverhampton Wndrs | D | 0-0 | (0-0) | | 25,466 |
| 38 | 13-May-12 | H | Newcastle United | W | 3-1 | (2-0) | Pienaar 16; Jelavic 27; Heitinga 65 | 39,517 |
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| FA Cup |
| Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 3 | 07-Jan-12 | H | Tamworth | W | 2-0 | (1-0) | Heitinga 5; Baines 79p | 27,564 |
| 4 | 27-Jan-12 | H | Fulham | W | 2-1 | (1-1) | Stracqualursi 27; Fellaini 73 | 25,300 |
| 5 | 18-Feb-12 | H | Blackpool | W | 2-0 | (2-0) | Drenthe 1; Stracqualursi 6 | 38,347 |
| QF | 17-Mar-12 | H | Sunderland | D | 1-1 | (1-1) | Cahill 23 | 38,875 |
| QFrr | 27-Mar-12 | A | Sunderland | W | 2-0 | (1-0) | Jelavic 24; Vaughan(og) 57 | 43,140 |
| SF | 14-Apr-12 | A | Liverpool | L | 1-2 | (1-0) | Jelavic 24 | 87,231 |
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|
| League Cup |
| Date | Ven | Opponent | Result | HT | Scorers | Attend |
| 2 | 24-Aug-11 | H | Sheffield United | W | 3-1 | (3-1) | Cresswell(og) 31; Anichebe 37; Arteta 42 | 17,173 |
| 3 | 21-Sep-11 | H | West Bromwich Albion | W | 2-1 | (0-0) | Fellaini 89; Neville 103 [aet] | 17,647 |
| 4 | 26-Oct-11 | H | Chelsea | L | 1-2 | (0-1) | Saha 83 [aet] | 23,070 |
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Score distributions by match - goals scored by row, and goals conceded by column. Each box shows the number of this season's matches with the resulting scoreline.